The postnatal injection of AAV9-FOXG1 rescues corpus callosum agenesis and other brain deficits in the mouse model of FOXG1 syndrome

Heterozygous mutations in the FOXG1 gene manifest as FOXG1 syndrome, a severe neurodevelopmental disorder characterized by structural brain anomalies, including agenesis of the corpus callosum, hippocampal reduction, and myelination delays. Despite the well-defined genetic basis of FOXG1 syndrome, t...

Full description

Bibliographic Details

Published in:	Molecular Therapy: Methods & Clinical Development
Main Authors:	Shin Jeon, Jaein Park, Shibi Likhite, Ji Hwan Moon, Dongjun Shin, Liwen Li, Kathrin C. Meyer, Jae W. Lee, Soo-Kyung Lee
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	FOXG1 AAV9 gene therapy corpus callosum dentate gyrus oligodendrocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050124000913