Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver

Interindividual variability in hepatic drug metabolism and transport is well-known, and genetic variation in pharmacogenes impacts the efficacy and safety of drug treatments. Recent reports have indicated that the minor allele of the nuclear transcription factor I/B (NFIB), rs28379954 T > C, affe...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Kathrin Klein, Oliver Burk, Roman Tremmel, Florian A. Buettner, Lea Kaestle, Werner Schroth, Thomas E. Muerdter, Diana Eccles, Anna-Christina Schmidt, Hanno Nieß, Ulrich M. Zanger, Matthias Schwab, Volker M. Lauschke
Format:	Article
Language:	English
Published:	Elsevier 2025-11-01
Subjects:	Cytochrome P450 CYP2D6 Nuclear Factor I family NFIB Drug metabolism Hepatocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661825004232