The role of s-palmitoylation in neurological diseases: implication for zDHHC family

S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain. zDHHC proteins form an autoacylation inte...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Dan Liao, Yutao Huang, Dan Liu, Haofuzi Zhang, Xinyu Shi, Xin Li, Peng Luo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	S-palmitoylation protein acyltransferase zDHHC glutamate receptor scaffold protein neurological diseases
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1342830/full

Similar Items

Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma
by: Beiyan Tang, et al.
Published: (2024-11-01)

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases
by: R. Elliot Murphy, et al.
Published: (2022-04-01)

Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases
by: Praveen B. S., et al.
Published: (2025-08-01)

Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential
by: Rongli Wang, et al.
Published: (2025-06-01)

Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases
by: Jiaying Peng, et al.
Published: (2024-08-01)

The ZDHHC13/ZDHHC17 subfamily: From biological functions to therapeutic targets of diseases
by: Ying Zhang, et al.
Published: (2024-11-01)

Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons
by: Julie P. Gupta, et al.
Published: (2023-03-01)

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies
by: Alice Main, et al.
Published: (2022-10-01)

ZDHHC11 Suppresses Zika Virus Infections by Palmitoylating the Envelope Protein
by: Dingwen Hu, et al.
Published: (2023-01-01)

ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis
by: Yaqi Mo, et al.
Published: (2024-12-01)

Open Biology: overview for special issue on dynamics of protein fatty acylation
by: Marilyn D. Resh
Published: (2021-09-01)

Palmitoylation regulators drive the progression of clear cell renal cell carcinoma through Inhibition of cuproptosis: insights into the role of ZDHHC18
by: Wei Xu, et al.
Published: (2025-06-01)

A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification
by: Naoko Adachi, et al.
Published: (2025-02-01)

ZDHHC21-driven S-palmitoylation of Themis regulates the function of T cells and maintains homeostatic balance
by: Caiyun Meng, et al.
Published: (2025-09-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
by: Minxuan Xu, et al.
Published: (2023-10-01)

Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease
by: Wenwen Li, et al.
Published: (2023-06-01)

Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation  in the Development and Immune Escape of Non-small Cell Lung Cancer
by: Wangcheng CHEN, et al.
Published: (2025-04-01)

ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma
by: Yang Wang, et al.
Published: (2024-01-01)

Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3
by: Chandan Sharma, et al.
Published: (2022-05-01)

Protein Palmitoylation in Leukocyte Signaling and Function
by: Xiaoyuan Yang, et al.
Published: (2020-10-01)

Expression of palmitoyl transferases in brain structures of mice genetically predisposed to depressive-like behavior
by: E. M. Kondaurova, et al.
Published: (2018-08-01)

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases
by: Rong Chen, et al.
Published: (2025-09-01)

ZDHHC5 as a central regulator in a palmitoylation-associated prognostic model for lung adenocarcinoma: insights from pan-cancer and experimental analyses
by: Sixuan Wu, et al.
Published: (2025-09-01)

CellPalmSeq: A curated RNAseq database of palmitoylating and de-palmitoylating enzyme expression in human cell types and laboratory cell lines
by: Angela R. Wild, et al.
Published: (2023-01-01)

Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity
by: Joju George, et al.
Published: (2015-04-01)

Inhibition of DHHC9-mediated CD36 palmitoylation lessens high-fat diet (HFD)-induced impairment of pubertal mammary gland development through the JNK-ERK pathway
by: Yiming Fu, et al.
Published: (2025-10-01)

DNA Methylation at cg18095732 Modulates ZDHHC20 Expression and Decreases Acne Vulgaris Risk
by: Gong K, et al.
Published: (2025-10-01)

Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
by: Gabriele A. Fontana, et al.
Published: (2019-11-01)

Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPARγ-driven lipid biosynthesis via regulating lipidome metabolic reprogramming
by: Junqi Shan, et al.
Published: (2024-08-01)

Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation
by: Madhur Shetty, et al.
Published: (2023-01-01)

Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate
by: Gregory J. Fredericks, et al.
Published: (2017-12-01)

Greasy GLUT1 maintains glioblastoma malignancy
by: Caiyun Liu, et al.
Published: (2021-11-01)

Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation.
by: Mingjie Bai, et al.
Published: (2024-01-01)

The anti-inflammatory role of zDHHC23 through the promotion of macrophage M2 polarization and macrophage necroptosis in large yellow croaker (Larimichthys crocea)
by: Ting Dai, et al.
Published: (2024-05-01)

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids
by: Xin Jin, et al.
Published: (2025-10-01)

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system
by: Christopher Icke, et al.
Published: (2021-02-01)

Acyltransferase zinc finger DHHC-type containing 2 aggravates gastric carcinoma growth by targeting Nrf2 signaling: A mechanism-based multicombination bionic nano-drug therapy
by: Luguang Liu, et al.
Published: (2024-04-01)

Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity
by: Ahmed A. Ramadan, et al.
Published: (2022-03-01)

RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer
by: Zhiqing Lin, et al.
Published: (2023-04-01)

Comprehensive Genome-Wide Investigation and Transcriptional Regulation of the DHHC Gene Family in Cotton Seed and Fiber Development
by: Saimire Silaiyiman, et al.
Published: (2024-06-01)