LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

Effective therapy for liver fibrosis is lacking. Here, we examined whether LP340, the lead candidate of a new-generation of hydrazide-based HDAC1,2,3 inhibitors (HDACi), decreases liver fibrosis. Liver fibrosis was induced by CCl4 treatment and bile duct ligation (BDL) in mice. At 6 weeks after CCl4...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Devadoss J. Samuvel, John J. Lemasters, C. James Chou, Zhi Zhong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	histone deacetylase liver fibrosis microRNA-23a oxidative stress SnoN TGFβ
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1386238/full