Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1, ADP·BeFx, and an ESCRT-III substrate peptide...

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Bibliographic Details

Published in:	eLife
Main Authors:	Nicole Monroe, Han Han, Peter S Shen, Wesley I Sundquist, Christopher P Hill
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-04-01
Subjects:	AAA ATPases ESCRT pathway Cryo-EM
Online Access:	https://elifesciences.org/articles/24487