Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strains

ABSTRACT Seasonal human coronaviruses (sHCoVs) cause 15%–30% of common colds. The reference strains used for research were isolated decades ago and have been passaged extensively, but contemporary sHCoVs have been challenging to study as they are notoriously difficult to grow in standard immortalize...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Matthew J. Gartner, Monique L. Smith, Clyde Dapat, Yi Wen Liaw, Thomas Tran, Randy Suryadinata, Joseph Chen, Guizhi Sun, Rory A. Shepherd, George Taiaroa, Michael Roche, Wen Shi Lee, Philip Robinson, Jose M. Polo, Kanta Subbarao, Jessica A. Neil
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-09-01
Subjects:	seasonal coronavirus air-liquid interface airway cultures AT2 cells
Online Access:	https://journals.asm.org/doi/10.1128/jvi.00684-25