Biomarkers for hypertrophic chondrocyte differentiation are associated with spatial cellular organisation and suggest endochondral ossification-like processes in osteoarthritic cartilage: An exploratory study

Background: In healthy articular cartilage, chondrocytes are found along arcades of collagen fibers as Single Strings. With onset of cartilage degeneration this pattern changes to Double Strings. In the course of osteoarthritis Small Clusters, and finally Big Clusters form. In highly degenerated art...

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Bibliographic Details

Published in:	Journal of Orthopaedic Translation
Main Authors:	Julius Michael Wolfgart, Lea Cathrine Grötzner, Sascha Hemayatkar-Fink, Maik Schwitalle, Florian Christof Bonnaire, Martina Feierabend, Marina Danalache, Ulf Krister Hofmann
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Angiogenesis Articular cartilage Endochondral ossification Hypertrophic differentiation Osteoarthritis Spatial chondrocyte organization
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214031X24000937