Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos

Abstract Background The high incidence of aneuploidy in early human development, arising either from errors in meiosis or postzygotic mitosis, is the primary cause of pregnancy loss, miscarriage, and stillbirth following natural conception as well as in vitro fertilization (IVF). Preimplantation gen...

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Bibliographic Details
Published in:Genome Medicine
Main Authors: Rajiv C. McCoy, Michael C. Summers, Abeo McCollin, Christian S. Ottolini, Kamal Ahuja, Alan H. Handyside
Format: Article
Language:English
Published: BMC 2023-10-01
Subjects:
Monosomy
Trisomy
Meiosis
Mitosis
IVF
Preimplantation genetic testing
Online Access:https://doi.org/10.1186/s13073-023-01231-1

Internet

https://doi.org/10.1186/s13073-023-01231-1

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