NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Abstract NSP7 (Non‐Structural Protein 7) of SARS‐CoV‐2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine‐48‐linked ubiquitination and subsequent proteasomal degra...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen
Format:	Article
Language:	English
Published:	Wiley 2025-09-01
Subjects:	antiviral therapies β‐TrCP1 FBXO5 non‐structural protein 7 TAF1 ubiquitination
Online Access:	https://doi.org/10.1002/advs.202500798