Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination

Background: During neuromuscular junction (NMJ) development, synapses are produced in excess. By sensing the activity-dependent release of ACh, adenosine, and neurotrophins, presynaptic receptors prompt axonal competition and loss of the unnecessary axons. The receptor action is mediated by synergis...

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Bibliographic Details

Published in:	Cells
Main Authors:	Neus Garcia, Cori Balañà, Maria A. Lanuza, Marta Tomàs, Víctor Cilleros-Mañé, Laia Just-Borràs, Josep Tomàs
Format:	Article
Language:	English
Published:	MDPI AG 2019-10-01
Subjects:	motor end-plate postnatal synapse elimination acetylcholine release muscarinic acetylcholine receptors pkc pka trkb receptors adenosine receptors
Online Access:	https://www.mdpi.com/2073-4409/8/11/1304