MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing.

Nucleoside reverse transcriptase translocation inhibitors (NRTTIs) are potent antiretroviral agents that block HIV replication. A comprehensive lead optimization campaign was undertaken to develop a novel long-acting NRTTI with the potential for extended-duration dosing for HIV prophylaxis. Broad ex...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Izzat T Raheem, Vinay Girijavallabhan, Kerry L Fillgrove, Shih Lin Goh, Carolyn Bahnck-Teets, Qian Huang, Fangbiao Li, Bang-Lin Wan, Gregory T O'Donnell, Jonathan B Patteson, Maria E Cilento, Amrith Bennet, Robert P Hayes, Srivanya Tummala, Carolyn McHale, Judyann Wiltsie, Joan Ellis, Ernest Asante-Appiah, Daria J Hazuda, Jeffrey Hale, Jay A Grobler, Min Xu, Tracy L Diamond, Ming-Tain Lai
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-08-01
Online Access:	https://doi.org/10.1371/journal.pbio.3003308