Two Amino Acid Substitutions Improve the Pharmacological Profile of the Snake Venom Peptide Mambalgin

Mambalgins are peptide inhibitors of acid-sensing ion channels type 1 (ASIC1) with potent analgesic effects in models of inflammatory and neuropathic pain. To optimize recombinant peptide production and enhance pharmacological properties, we developed a mutant analog of mambalgin-1 (Mamb) through mo...

Full description

Bibliographic Details

Published in:	Toxins
Main Authors:	Dmitry I. Osmakov, Timur A. Khasanov, Ekaterina E. Maleeva, Vladimir M. Pavlov, Victor A. Palikov, Olga A. Belozerova, Sergey G. Koshelev, Yuliya V. Korolkova, Igor A. Dyachenko, Sergey A. Kozlov, Yaroslav A. Andreev
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	mutagenesis ASIC channels electrophysiology peptide analgesic effect
Online Access:	https://www.mdpi.com/2072-6651/17/3/101