An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study

Abstract Background Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis. A refined understanding of age-based polygenic ri...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng, Mulong Du
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Age-specific genome-wide association studies Early-onset prostate cancer Phenome-wide association studies Polygenic risk score UK biobank
Online Access:	https://doi.org/10.1186/s12967-024-05190-y