Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag

Human BCA2/RNF115/Rabring7 (hBCA2) is a RING type E3 ubiquitin ligase with the ability of autoubiquitination or promoting protein ubiquitination. It also acts as a host restriction factor has BST2-dependent and BST2-independent antiviral activity to inhibit the release of HIV-1. In a previous study,...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Meng Qu, Weiran Wang, Weiting Li, Jiaming Cao, Xin Zhang, Chu Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Hui Wu, Wei Kong, Xianghui Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Subjects:	host restriction factor BCA2 NF-κB transcription HIV-1 Gag FIV Gag
Online Access:	https://www.frontiersin.org/article/10.3389/fmicb.2020.01230/full