IgG sialylation occurs in B cells pre antibody secretion

Sialic acids as terminal sugar residues on cell surface or secreted proteins have many functional roles. In particular, the presence or absence of α2,6-linked sialic acid residues at the immunoglobulin G (IgG) Fc fragment can switch IgG effector functions from pro- to anti-inflammatory activity. IgG...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Anja Werner, Maja Hanić, Olga O. Zaitseva, Gordan Lauc, Anja Lux, Lars Nitschke, Falk Nimmerjahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Subjects:
immunoglobulin G
sialic acid
autoantibody
B cell
sialylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1402000/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1402000/full

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