IgG sialylation occurs in B cells pre antibody secretion

Sialic acids as terminal sugar residues on cell surface or secreted proteins have many functional roles. In particular, the presence or absence of α2,6-linked sialic acid residues at the immunoglobulin G (IgG) Fc fragment can switch IgG effector functions from pro- to anti-inflammatory activity. IgG...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Anja Werner, Maja Hanić, Olga O. Zaitseva, Gordan Lauc, Anja Lux, Lars Nitschke, Falk Nimmerjahn
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	immunoglobulin G sialic acid autoantibody B cell sialylation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1402000/full

Similar Items

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo
by: Anja Schaffert, et al.
Published: (2020-01-01)

The role of sialylation in gynecologic cancers
by: Szu-Ting Yang, et al.
Published: (2023-09-01)

Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation
by: Christopher Beneduce, et al.
Published: (2023-08-01)

Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases
by: Jannis Wißfeld, et al.
Published: (2024-03-01)

Sialylation as a checkpoint for inflammatory and complement-related retinal diseases
by: Yiduo Min, et al.
Published: (2025-06-01)

Prospects for the use of sialylated immunoglobulins in the treatment of different diseases
by: Yu. V. Markina, et al.
Published: (2020-06-01)

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women
by: Cecilia Engdahl, et al.
Published: (2018-05-01)

Lectin-Based Method for Deciphering Human Milk IgG Sialylation
by: Jolanta Lis-Kuberka, et al.
Published: (2019-10-01)

Sialic acids on T cells are crucial for their maintenance and survival
by: Michael Schmidt, et al.
Published: (2024-06-01)

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause
by: Priti Gupta, et al.
Published: (2023-09-01)

An Engineered Pathway for Production of Terminally Sialylated N-glycoproteins in the Periplasm of Escherichia coli
by: Jing Zhu, et al.
Published: (2020-04-01)

IgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy
by: Somanath Kallolimath, et al.
Published: (2024-10-01)

The therapeutic potential of sialylated Fc domains of human IgG
by: Richard J. Pleass
Published: (2021-01-01)

Lectin staining and Western blot data showing differential sialylation of nutrient-deprived cancer cells to sialic acid supplementation
by: Haitham A. Badr, et al.
Published: (2015-12-01)

Biological Functions and Analytical Strategies of Sialic Acids in Tumor
by: Xiaoman Zhou, et al.
Published: (2020-01-01)

Desialylation of Blood Plasma Lipoproteins by Exogenous Sialidase
by: Evgeny Bezsonov, et al.
Published: (2022-11-01)

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates
by: Zhixin Cyrillus Tan, et al.
Published: (2023-07-01)

Anti-pan-neurofascin IgG3: insights about an emerging autoimmune nodoparanodopathy
by: Gabriel Erzinger, et al.
Published: (2025-09-01)

Mimetics of Sialyl Lewisx: The Pre-Organization of the Carboxylic Acid is Essential for Binding to Selectins
by: Alexander Titz, et al.
Published: (2007-04-01)

Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation
by: Priti Gupta, et al.
Published: (2024-04-01)

Sialic Acids in Health and Disease
by: Gerardo N. Guerrero-Flores, et al.
Published: (2025-03-01)

Expression Profiling and Glycan Engineering of IgG Subclass 1–4 in Nicotiana benthamiana
by: Somanath Kallolimath, et al.
Published: (2020-07-01)

LC-MS/MS-Based Site-Specific N-Glycosylation Analysis of VEGFR-IgG Fusion Protein for Sialylation Assessment Across IEF Fractions
by: Kwang Hoe Kim, et al.
Published: (2024-11-01)

The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity
by: Sina Gordan, et al.
Published: (2019-12-01)

Role of Sialic Acids in Central Nervous System Immune Response
by: Karolina Narejko, et al.
Published: (2025-06-01)

Lipid-bound sialic acid (LSA) in liver diseases of different etiologies
by: Lech Chrostek, et al.
Published: (2011-04-01)

Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis
by: Chenyang Hu, et al.
Published: (2025-06-01)

Comprehensive analysis of sialylation-related genes and construct the prognostic model in sepsis
by: Linfeng Tao, et al.
Published: (2024-08-01)

Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis
by: Yannic C. Bartsch, et al.
Published: (2018-06-01)

Construction of an Escherichia coli chassis for efficient biosynthesis of human-like N-linked glycoproteins
by: Zixin Bao, et al.
Published: (2024-03-01)

Sialic acid blockade inhibits the metastatic spread of prostate cancer to boneResearch in context
by: Kirsty Hodgson, et al.
Published: (2024-06-01)

Sialic Acids and Their Influence on Human NK Cell Function
by: Philip Rosenstock, et al.
Published: (2021-01-01)

Dendritic Cells: a Spot on Sialic Acid
by: Hélio João Crespo, et al.
Published: (2013-12-01)

Patterns of sialyl-Lewis X expression predict gastric histopathology
by: Nancy Vargas, et al.
Published: (2025-06-01)

Dysregulated Sialylation in Cancer: From Immunosuppressive Microenvironment to Siglec-Targeted Therapeutics
by: Yuecheng Zhang, et al.
Published: (2025-09-01)

Diversity of IgG autoantibodies of 4 Chinese intravenous immunoglobulins
by: Xiaochen YAN, et al.
Published: (2023-12-01)

Sialylation is involved in cell fate decision during development, reprogramming and cancer progression
by: Fenjie Li, et al.
Published: (2018-11-01)

Sialylation: A Cloak for Tumors to Trick the Immune System in the Microenvironment
by: Xiaoman Zhou, et al.
Published: (2023-06-01)

Mechanism of action for Troxerutin targeting the sialylation-related gene EGLN3 for the treatment of LUAD
by: Yanan Wu, et al.
Published: (2025-03-01)

When a negative (charge) is not a positive: sialylation and its role in cancer mechanics and progression
by: Issa Funsho Habeeb, et al.
Published: (2024-11-01)