Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells

Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases. Cellular damage caused by oxidative damage is reversed by several pathways, one of which is the antioxidant r...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Corinne Hamblet, Karin Björhall, Susann Busch, Ulf Gehrmann, Lisa Öberg, Rebekka Kubisch-Dohmen, Sonja Haas, Manish K. Aneja, Johannes Geiger, Carsten Rudolph, Ellinor Hornberg
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	antioxidant response cmRNA lung NRF2 KEAP1
Online Access:	https://www.mdpi.com/2076-3921/13/8/924