Evaluation of the Robustness Verification of Downstream Production Process for Inactivated SARS-CoV-2 Vaccine and Different Chromatography Medium Purification Effects

Background: Large-scale vaccine production requires downstream processing that focuses on robustness, efficiency, and cost-effectiveness. Methods: To assess the robustness of the current vaccine production process, three batches of COVID-19 Omicron BA.1 strain hydrolytic concentrated solutions were...

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Bibliographic Details

Published in:	Vaccines
Main Authors:	Jia-Hui Pang, Chang-Fu Guo, Peng-Liang Hao, Sheng-Li Meng, Jing Guo, Dou Zhang, Ya-Qi Ji, Ping-Gang Ming
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Subjects:	SARS-CoV-2 Vero cells downstream process purification vaccines size-exclusion chromatography
Online Access:	https://www.mdpi.com/2076-393X/12/1/56