Tsg101 Regulates PI(4,5)P2/Ca2+ Signaling for HIV-1 Gag Assembly

Our previous studies identified the 1,4,5-inositol triphosphate receptor (IP3R), a channel mediating release of Ca2+ from ER stores, as a cellular factor differentially associated with HIV-1 Gag that might facilitate ESCRT function in virus budding. Channel opening requires activation that is initi...

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Bibliographic Details
Published in:Frontiers in Microbiology
Main Authors: Lorna S Ehrlich, Sara ePhotiadis, Gisselle N Medina, Paul B Whittredge, Justin W Taraska, Susan eWatanabe, Carol A Carter
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Subjects:
HIV-1
Ca2+ signaling
IP3R
Gag assembly
L Domain
Tsg101
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00234/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00234/full

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