Integrated Transcriptome and Proteome Analyses Reveal the Regulatory Role of miR-146a in Human Limbal Epithelium via Notch Signaling

MiR-146a is upregulated in the stem cell-enriched limbal region vs. central human cornea and can mediate corneal epithelial wound healing. The aim of this study was to identify miR-146a targets in human primary limbal epithelial cells (LECs) using genomic and proteomic analyses. RNA-seq combined wit...

Full description

Bibliographic Details

Published in:	Cells
Main Authors:	Adam J. Poe, Mangesh Kulkarni, Aleksandra Leszczynska, Jie Tang, Ruchi Shah, Yasaman Jami-Alahmadi, Jason Wang, Andrei A. Kramerov, James Wohlschlegel, Vasu Punj, Alexander V. Ljubimov, Mehrnoosh Saghizadeh
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Subjects:	cornea miRNA miR-146a Notch Numb limbal stem cells
Online Access:	https://www.mdpi.com/2073-4409/9/10/2175