Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products

Summary: Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic infl...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Patricia Castillo-dela Cruz, Alanna G. Wanek, Pawan Kumar, Xiaojing An, Waleed Elsegeiny, William Horne, Adam Fitch, Ansen H.P. Burr, Kathyayini P. Gopalakrishna, Kong Chen, Barbara A. Methé, Scott W. Canna, Timothy W. Hand, Jay K. Kolls
Format:	Article
Language:	English
Published:	Elsevier 2019-11-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124719313567