Investigation of mRNA expression levels of DNA damage response genes in Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma: a pilot study

Abstract Merkel Cell Polyomavirus (MCPyV) is recognized as the major aetiological agent of Merkel Cell Carcinoma (MCC), an aggressive skin tumor. MCPyV-mediated oncogenesis is strictly dependent on viral integration and the expression of a truncated form of the Large T Antigen (LT). Moreover, like o...

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Bibliographic Details

Published in:	Discover Oncology
Main Authors:	Sara Passerini, Matteo Fracella, Amedeo Ferlosio, Ugo Moens, Carolina Scagnolari, Guido Antonelli, Marco Ciotti, Valeria Pietropaolo
Format:	Article
Language:	English
Published:	Springer 2025-05-01
Subjects:	MCPyV MCC DDR LT ATM ATR
Online Access:	https://doi.org/10.1007/s12672-025-02651-8