Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells.

Mutations in the inositol polyphosphate 5-phosphatase OCRL1 cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure. We noted that cell types affected in Lowe Syndrome are highly polarized, and therefore we studied OCRL1 in epithelial cells as they mature from isolated indivi...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Adam G Grieve, Rachel D Daniels, Elena Sanchez-Heras, Matthew J Hayes, Stephen E Moss, Karl Matter, Martin Lowe, Timothy P Levine
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024044&type=printable