Enhancement of complement-dependent cytotoxicity by linking factor-H derived short consensus repeats 19-20 to CD20 antibodies

Antibody-mediated complement-dependent cytotoxicity (CDC) on malignant cells is regulated by several complement control proteins, including the inhibitory complement factor H (fH). fH consists of 20 short consensus repeat elements (SCRs) with specific functional domains. Previous research revealed t...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Lena Prantl, Philipp Heider, Lisa Bergmeister, Katharina Calana, Jan-Paul Bohn, Dominik Wolf, Zoltan Banki, Andreas Bosch, Maximilian Plach, Georg Huber, Silke Schrödel, Christian Thirion, Heribert Stoiber
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	CLL complement-dependent cytotoxicity ofatumumab rituximab obinutuzumab complement factor H
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1379023/full