Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function.

In the search for a cure for HIV-1 infection, histone deacetylase inhibitors (HDACi) are being investigated as activators of latently infected CD4 T cells to promote their targeting by cytotoxic T-lymphocytes (CTL). However, HDACi may also inhibit CTL function, suggesting different immunotherapy app...

Full description

Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Matthew Pace, James Williams, Ayako Kurioka, Andrew B Gerry, Bent Jakobsen, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, CHERUB Investigators
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-08-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005782&type=printable