Modelling of immune infiltration in prostate cancer treated with HDR-brachytherapy using Raman spectroscopy and machine learning

Abstract Prostate cancer is characterized by an immunosuppressive tumour environment. This work combines Raman spectroscopy with group-and-bases-restricted non-negative matrix factorization (GBR-NMF) and machine learning to assemble models of immune cell densities within the needle-core biopsies of...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Sandra N. Popescu, Kirsty Milligan, Mitchell Wiebe, Alejandra Fuentes, Joan M. Brewer, Christina K. Haston, Julian J. Lum, Samantha Punch, Alejandra Raudales, Alexandre G. Brolo, Juanita M. Crook, Jeffrey L. Andrews, Andrew Jirasek
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Online Access:	https://doi.org/10.1038/s41598-025-20107-5