Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

IntroductionHuman Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. Moreover, these cells may be easily induced in vitro making them interesting for cell therapy.MethodsWe characterized this population of in...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Nicolas Sailliet, Hoa-Le Mai, Amandine Dupuy, Gaëlle Tilly, Cynthia Fourgeux, Martin Braud, Magali Giral, Jean-Michel Robert, Nicolas Degauque, Richard Danger, Jeremie Poschmann, Sophie Brouard
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	regulatory B cell regulation single cell RNAseq tolerance GZMB LTA
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183714/full