Structural and Dynamic Analyses of Pathogenic Variants in <i>PIK3R1</i> Reveal a Shared Mechanism Associated among Cancer, Undergrowth, and Overgrowth Syndromes

The PI3K enzymes modify phospholipids to regulate cell growth and differentiation. Somatic variants in PI3K are recurrent in cancer and drive a proliferative phenotype. Somatic mosaicism of <i>PIK3R1</i> and <i>PIK3CA</i> are associated with vascular anomalies and overgrowth...

詳細記述

書誌詳細

出版年:	Life
主要な著者:	Nikita R. Dsouza, Catherine E. Cottrell, Olivia M. T. Davies, Megha M. Tollefson, Ilona J. Frieden, Donald Basel, Raul Urrutia, Beth A. Drolet, Michael T. Zimmermann
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2024-02-01
主題:	precision medicine genomics genomic data interpretation overgrowth undergrowth PI3K
オンライン･アクセス:	https://www.mdpi.com/2075-1729/14/3/297