Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters

Abstract Rotating frame relaxation (RFR) techniques provide robust and sensitive quantitative MRI (qMRI) metrics able to detect subtle alterations of brain tissue integrity in multiple neurological disorders. We performed a cross-sectional qMRI study in 16 patients with Multiple System Atrophy (MSA)...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Antonietta Canna, Silvia Mangia, Shalom Michaeli, Sara Ponticorvo, Maria Claudia Russillo, Valentina Andreozzi, Renzo Manara, Francesco Di Salle, Marina Picillo, Paolo Barone, Fabrizio Esposito, Maria Teresa Pellecchia
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Adiabatic T1ρ T2ρ MT R1 R2* MSA
Online Access:	https://doi.org/10.1038/s41598-025-10812-6