Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction

ABSTRACT All organisms produce an intracellular Zn2+-dependent enzyme, phosphomannose isomerase (PMI) or mannose-6 phosphate isomerase, that catalyzes the reversible conversion of mannose-6-phosphate and fructose-6-phosphate during sugar metabolism and polysaccharide biosynthesis. Unexpectedly, we d...

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出版年:	mBio
主要な著者:	Shraboni Dutta, Vipin S. Rana, Brian T. Backstedt, Anil K. Shakya, Chrysoula Kitsou, Ozlem B. Yas, Alexis A. Smith, Michael H. Ronzetti, Rachel M. Lipman, Sarai Araujo-Aris, Xiuli Yang, Ganesha Rai, Yi-Pin Lin, Osnat Herzberg, Utpal Pal
フォーマット:	論文
言語:	英語
出版事項:	American Society for Microbiology 2025-03-01
主題:	moonlighting lyme disease pathogen phosphomannose isomerase host-pathogen interaction
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/mbio.03609-24