Targeting EGFR allosteric site with marine-natural products of Clathria Sp.: A computational approach

The EGFR-C797S resistance mutation to third-generation drugs has been overcome by fourth-generation inhibitors, allosteric inhibitors, namely EAI045 and has reached phase 3 clinical trials, so the Allosteric Site is currently an attractive target for development. In this study, researchers are inter...

Full description

Bibliographic Details

Published in:	Current Research in Structural Biology
Main Authors:	Nurisyah, Dwi Syah Fitra Ramadhan, Ratnasari Dewi, Asyhari asikin, Dwi Rachmawaty Daswi, Adriyani adam, Chaerunnimah, Sunarto, Rafika, Artati, Taufik Muhammad Fakih
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Marine-natural products EGFR Allosteric inhibitor
Online Access:	http://www.sciencedirect.com/science/article/pii/S2665928X24000023