Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

BackgroundSubjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). We aim to characterize the impact of IMID on the immune response to M. tuberculosis (Mtb) in pat...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Chiara Farroni, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Gilda Cuzzi, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Giovanni Delogu, Ivana Palucci, Settimia Sbarra, Alessandra Aiello, Andrea Picchianti-Diamanti, Gina Gualano, Fabrizio Palmieri, Delia Goletti, Elisa Petruccioli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	tuberculosis rheumatoid arthritis Th1 antigen-specific response AIM assay, IFN-γ MGIA
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484143/full