Analytical validation (accuracy, reproducibility, limit of detection) and gene expression analysis of FoundationOneRNA assay for fusion detection in 189 clinical tumor specimens.

Targeted DNA-based comprehensive genomic profiling (CGP) to detect clinically significant alterations is increasingly becoming standard for patients with advanced or recurrent cancer. RNA-based sequencing, however, may improve performance of fusion detection. We developed a robust targeted RNA seque...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Daokun Sun, Richard S P Huang, Michelle Green, Chenming Cui, Saumya D Sisoudiya, Andrej Savol, Chang Xu, Cui Guo, Joel Skoletsky, Justin M Allen, Khaled Tolba, Varun Pattani, Alyssa Tarzia, Jennifer Whiting, Yanhua Tang, Lee A Albacker, Christine Vietz, Michael Datto, Jie He, William Richard Jeck
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0329697