Cellular senescence in the pathogenesis of pulmonary arterial hypertension: the good, the bad and the uncertain

Senescence refers to a cellular state marked by irreversible cell cycle arrest and the secretion of pro-inflammatory and tissue-remodeling factors. The senescence associated secretory phenotype (SASP) impacts the tissue microenvironment and provides cues for the immune system to eliminate senescent...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Elmira Safaie Qamsari, Duncan J. Stewart
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	endothelial cells senescence PAH pulmonary hypertension senotherapeutic pulmonary arterial hypertension
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1403669/full