3D QSAR of Pyrrolo Pyrimidine and Thieno Pyrimidines as Human Thymidylate Synthase Inhibitors
Thymidylate synthase (TS) is a crucial enzyme for DNA biosynthesis and many nonclassical lipophilic antifolates targeting this enzyme are quite efficient and encouraging as antitumor drugs. We report 3D-QSAR analyses on pyrrolo pyrimidine and thieno pyrimidine antifolates to contemplate the mechanis...
| Published in: | E-Journal of Chemistry |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Online Access: | http://dx.doi.org/10.1155/2012/201937 |