Osimertinib Did Not Respond to a Pulmonary Adenocarcinoma with Triple Mutations of Epidermal Growth Factor Receptor, G719S, T790M and S768I

Uncommon epidermal growth factor receptor (EGFR) gene mutations include G719S, T790M and S768I. T790M gatekeeper mutation is the most frequent mechanism of acquired drug resistance to first- and second-generation EGFR-tyrosine kinase inhibitors (TKIs). Osimertinib is a specific EGFR-TKI to overcome...

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發表在:	Case Reports in Oncology
Main Authors:	Seigo Minami, Shouichi Ihara, Tsunehiro Tanaka, Hideyasu Okada, Kazuki Hashimoto, Kiyoshi Komuta
格式:	Article
語言:	英语
出版:	Karger Publishers 2019-02-01
主題:	Uncommon epidermal growth factor receptor (EGFR) mutation Osimertinib EGFR exon 18 G719S EGFR exon 20 S768I EGFR exon 20 T790M
在線閱讀:	https://www.karger.com/Article/FullText/497316