Oncogenic β-catenin mutations evade pH-regulated degradation

β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilita...

Full description

Bibliographic Details

Published in:	Molecular & Cellular Oncology
Main Authors:	Bree K. Grillo-Hill, Katharine A. White
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Subjects:	β-catenin intracellular ph wnt signaling ubiquitination proteasome β-trcp tumorigenesis
Online Access:	http://dx.doi.org/10.1080/23723556.2018.1554470