Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as...

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Bibliographic Details

Published in:	SLAS Discovery
Main Authors:	Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Subjects:	Biomolecular condensates High content screening single molecule tracking Split luciferase NanoBRET Dynamics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2472555225000139