Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity

Mitochondrial dysfunction is implicated in the pathogenesis of multiple neurological diseases, but elucidation of underlying mechanisms is limited experimentally by the inability to damage specific mitochondria in defined neuronal groups. We developed a precision chemoptogenetic approach to target n...

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Bibliographic Details

Published in:	eLife
Main Authors:	Wenting Xie, Binxuan Jiao, Qing Bai, Vladimir A Ilin, Ming Sun, Charles E Burton, Dmytro Kolodieznyi, Michael J Calderon, Donna B Stolz, Patricia L Opresko, Claudette M St Croix, Simon Watkins, Bennett Van Houten, Marcel P Bruchez, Edward A Burton
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-03-01
Subjects:	mitochondria chemoptogenetics respiration motor function cell death
Online Access:	https://elifesciences.org/articles/51845