Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells

Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same subcellular loci. Given that γ-secretase is i...

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Bibliographic Details

Published in:	Sensors
Main Authors:	Mei C. Q. Houser, Shane P. C. Mitchell, Priyanka Sinha, Brianna Lundin, Oksana Berezovska, Masato Maesako
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	γ-secretase endosome and lysosome membrane properties Aβ
Online Access:	https://www.mdpi.com/1424-8220/23/5/2651