New regimens of benznidazole for the treatment of chronic Chagas disease in adult participants in indeterminate form or with mild cardiac progression (NuestroBen study): protocol for a phase III randomised, multicentre non-inferiority clinical trial

Introduction Chagas disease (CD) is one of the most neglected diseases in the world. In Latin America, CD is endemic in 21 countries, with an estimated 70 million people at risk of infection. Current treatments are limited to two nitroheterocyclic compounds: nifurtimox and benznidazole (BZN). Each h...

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Bibliographic Details

Published in:	BMJ Open
Main Authors:	Kert Viele, Michel Vaillant, Sergio Sosa-Estani, Craig Tipple, María-Jesús Pinazo, Lourdes Ortiz, Wilson Garcia, Alejandro Schijman, Israel Molina, Tayná Marques, Colin Forsyth, Fabiana Barreira, Carola Lombas, Bethania Blum de Oliveira, Mónica Laserna, Maria del Carmen Bangher, Rosmiro Javier Fernández, Susana Lloveras, Marisa Liliana Fernández, Pablo Scapellato, Patricia Patterson, Otacilio C Moreira, Lineth García, Silvia Longhi, Laurent Fraisse, Andrea Silvestre-Sousa
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-09-01
Online Access:	https://bmjopen.bmj.com/content/15/9/e098079.full