Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation

Abstract Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development relies on the empiric assumption that cell-penetrating peptides (CP...

Full description

Bibliographic Details

Published in:	Fluids and Barriers of the CNS
Main Authors:	Marco Cavaco, Patrícia Fraga, Javier Valle, Ruben D. M. Silva, Lurdes Gano, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Blood–brain barrier (BBB) Blood–brain barrier peptide shuttles (BBBpS) Brain delivery Cell-penetrating peptides (CPPs) Neurological disorders
Online Access:	https://doi.org/10.1186/s12987-024-00545-5