Tumor-suppressive MEG3 induces microRNA-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/MYC axis

Abstract Background Chemoresistance serves as a huge obstacle for acute myeloid leukemia (AML) patients. To counteract the chemoresistance in AML cells, we discussed the role of maternally expressed gene 3 (MEG3) in arabinocytosine (AraC) chemoresistance in AML cells. Methods MEG3, microRNA (miR)-49...

Full description

Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Airong Wang, Yufei Chen, Luyao Shi, Mengya Li, Lingling Li, Shujuan Wang, Chong Wang
Format:	Article
Language:	English
Published:	BMC 2022-06-01
Subjects:	Acute myeloid leukemia Chemotherapy Maternally expressed gene 3 microRNA-493-5p Methyltransferase-like 3
Online Access:	https://doi.org/10.1186/s12967-022-03456-x