Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation

Mevalonate Kinase Deficiency (MKD) is a rare inborn disease belonging to the family of periodic fever syndromes. The MKD phenotype is characterized by systemic inflammation involving multiple organs, including the nervous system. Current anti-inflammatory approaches to MKD are only partially effecti...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Erika Rimondi, Erica Valencic, Alberto Tommasini, Paola Secchiero, Elisabetta Melloni, Annalisa Marcuzzi
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Subjects:	mevalonate inflammation drug repositioning rare disease
Online Access:	https://www.mdpi.com/2218-273X/11/10/1438