Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer’s disease

Abstract There is increasing evidence that cerebrospinal fluid (CSF) circulation plays a key role in the pathophysiology of Alzheimer’s disease (AD), although the underlying mechanisms remain poorly understood. This study evaluated CSF circulation in patients with AD using magnetic resonance imaging...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Weiqi Lin, Huijuan Chen, Zhanrong Zhang, Yiying Zhang, Xingqun Wang, Yihao Guo, Haodong Qin, Tao Liu, Feng Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	Cerebrospinal fluid circulation DTI-ALPS Choroid plexus volume Cerebrospinal fluid volume Alzheimer’s disease
Online Access:	https://doi.org/10.1038/s41598-025-15923-8