Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells

The study aimed to optimize and develop novel PEGylated co-loaded nanoliposome entrapped with paclitaxel (PTX) and 6-gingerol (Gn) (PEG-Lipo-PTX-Gn) by response surface methodology (RSM) approach to prevent the diffusion and resistant-related issues of PTX in oncotherapy. Physiochemical characteriza...

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Bibliographic Details

Published in:	Artificial Cells, Nanomedicine, and Biotechnology
Main Authors:	Priyadharshini Thangavelu, Kaavya Gunasekaran, Senthilkumar Periyathambi, Abeer Hashem, Nouf H. Alotaibi, Elsayed Fathi Abd_Allah, Rama Jayaraj, Naveen Kumar Kalagatur, Suja Samiappan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Paclitaxel 6-gingerol response surface methodology synergism apoptosis PEGylated liposome
Online Access:	https://www.tandfonline.com/doi/10.1080/21691401.2025.2566711