Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Summary Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from individuals with diabetes and...

Full description

Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-07-01
Online Access:	https://doi.org/10.1038/s41419-023-05906-w