Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and pro...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yuheng Zou, Hongying Zhang, Feng Bi, Qiulin Tang, Huanji Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	cancer treatment cell proliferation and migration cholesterol metabolism drug target squalene epoxidase
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.938502/full