Neuroplastin 65 deficiency leads to the impairment of visual function through affecting ribbon synapse in retina of mice

Neuroplastin 65 (NP65) is a synapse-enriched glycoprotein in the central nervous system and is implicated in synaptic plasticity. In the present study, we found that NP65 knockout (NP65 KO) mice exhibit impaired visual function, including reductions in the amplitude of b-wave in scotopic flash elect...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Jiu-jiang Zeng, Ling Chen, Li-fen Liu, Jia-lu Wang, Jie Cheng, Ya-ni Zheng, Lei Zhang, Xiao-ming Zhang, Qiong-lan Yuan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	neuroplastin 65 visual function ribbon synapse ribeye retina
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1558334/full