Co-Translational Quality Control Induced by Translational Arrest

Genetic mutations, mRNA processing errors, and lack of availability of charged tRNAs sometimes slow down or completely stall translating ribosomes. Since an incomplete nascent chain derived from stalled ribosomes may function anomalously, such as by forming toxic aggregates, surveillance systems mon...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Yoshitaka Matsuo, Toshifumi Inada
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Subjects:
Online Access:https://www.mdpi.com/2218-273X/13/2/317